Two-photon absorption fluorescence (TPAF) has been demonstrated as
a powerful tool for bioimaging applications, particularly for deep-tissue
imaging applications. However the weak fluorescence signals from many fluorophores
impose significant limitations to the maximum depths (usually around several
hundred microns) that can be imaged with reasonable signal-to-noise ratios.
Also, medical use is limited due to the fact that cadmium is a toxic element
and is usually a constituent of these fluorophores. Recently quantum dots have
attracted attention since they have significant advantages over other
fluorophores. These advantages include: broad absorption spectra and more readily
tunable emission options, high quantum yields, relatively high photochemical
stability, and relatively large two-photon absorption cross sections. However, cadmium
toxicity is still an issue in quantum dot technology and needs to be eliminated
if medical applications are to be pursued.
Researchers at the University of New Mexico have developed a
method for eliminating cadmium toxicity in quantum dots. This technology shields
the toxicity inside the quantum dot by use of a nanoshell. This technology
fulfills the need for a high-brightness, nonphotobleaching, and nontoxic fluorophore
as well as creates the ability for new medical research and clinical
STC has filed intellectual property on this exciting new technology and is currently exploring commercialization options. If you are interested in information about this or other technologies, please contact Arlene Mirabal at firstname.lastname@example.org or 505-272-7886.