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Project TitleMultilayered Plasmonic Quantum Dot
Track Code2012-024
Short Description

Researchers at the University of New Mexico have developed a method for eliminating cadmium toxicity in quantum dots.

Abstract

This technology shields the toxicity inside the quantum dot by use of a nanoshell. This technology fulfills the need for a high-brightness, nonphotobleaching, and nontoxic fluorophore as well as creates the ability for new medical research and clinical applications.

 
Tagsquantum dots, Medical Imaging using quantum dots
 
Posted DateDec 8, 2011 1:24 PM

Researcher

Name
Ravinder Jain
Mike Klopfer

Manager

Name
Briana Wobbe

Background

Two-photon absorption fluorescence (TPAF) has been demonstrated as a powerful tool for bioimaging applications, particularly for deep-tissue imaging applications. However the weak fluorescence signals from many fluorophores impose significant limitations to the maximum depths (usually around several hundred microns) that can be imaged with reasonable signal-to-noise ratios. Also, medical use is limited due to the fact that cadmium is a toxic element and is usually a constituent of these fluorophores. Recently quantum dots have attracted attention since they have significant advantages over other fluorophores. These advantages include: broad absorption spectra and more readily tunable emission options, high quantum yields, relatively high photochemical stability, and relatively large two-photon absorption cross sections. However, cadmium toxicity is still an issue in quantum dot technology and needs to be eliminated if medical applications are to be pursued.

Technology Description

Researchers at the University of New Mexico have developed a method for eliminating cadmium toxicity in quantum dots. This technology shields the toxicity inside the quantum dot by use of a nanoshell. This technology fulfills the need for a high-brightness, nonphotobleaching, and nontoxic fluorophore as well as creates the ability for new medical research and clinical applications.

Advantages/Applications

  • Eliminates cadmium toxicity
  • Enhances brightness
  • Enhances TPAF signal
  • Larger two-photon absorption cross section compared to traditional fluorophores
  • Allows for current quantum dot technology to be used in medical applications
  • Applications in biomedical and deep-tissue imaging

Publications

INQUIRES

STC has filed intellectual property on this exciting new technology and is currently exploring commercialization options. If you are interested in information about this or other technologies, please contact Arlene Mirabal at amirabal@stc.unm.edu or 505-272-7886.

Files

File Name Description
9,267,889 Issued Patent None Download

Intellectual Property

Patent Number Issue Date Type Country of Filing
9,267,889 Feb 23, 2016 Utility United States