Go to Top
INVENTOR LOGIN

Details

Project TitleRhPV1 as a Model for HPV - Induced Cancers
Track Code2003-007
Short Description

Rhesus papillomavirus type 1 (RhPV1) causes the same spectrum of anogenital infections and disease in rhesus monkeys as high-risk HPVs in humans.

Abstract

 We used the cloned RhPV1 viral DNA to synthesize produce high titers of Infectious virions in vitro and followed experimental infections in five female rhesus monkeys; the results demonstrate the following: --RhPV1 virus stocks are infectious in vivo; animal seroconvert --3/5 animals show evidence of low grade squamous intraepithelial lesions (LGSIL) --Persistent RhPV1 genomes are found in Pap smears from the animals The patent for this invention is issued; please see the attachment below to review.

 
Tagshpv, RhPV1, Papillomaviruses, std
 
Posted DateJul 18, 2012

Researcher

Name
Michelle Ozbun

Manager

Name
Jovan Heusser

Background

Papillomaviruses (PVs) are a large family of non-enveloped, icosahedral DNA viruses with a particle diameter of 50-55 nm. PVs display remarkable species specificity and strong cellular tropism, and produce benign and malignant tumors in their natural hosts. Humans are the only known hosts for human papillomaviruses (HPVs); attempts to transfer HPVs to other species have failed. HPVs commonly associated with malignant conversion include those involved in epidermodysplasia verruciformis (e.g., HPV5 and HPV8) and a subset of the types that infect the anogenital region. Examples of high-risk anogenital viruses include HPV types 16, 18, 31, 33 and 51. In fact, the high-risk HPV infections are involved in greater than 99% of all cervical malignancies, and cervical cancer is the second leading cause of cancer-related deaths in women worldwide. Although two newly FDA approved HPV vaccines show promise for reducing infections and related disease from HPV high risk types 16 and 18, the longevity of the protection is unclear, cross protection against the other 13 oncogenic types is questionable, and accessibility (affordability) to those in greatest need is yet to be seen.

Technology Description

Rhesus papillomavirus type 1 (RhPV1) causes the same spectrum of anogenital infections and disease in rhesus monkeys as high-risk HPVs in humans. We used the cloned RhPV1 viral DNA to synthesize produce high titers of Infectious virions in vitro and followed experimental infections in five female rhesus monkeys; the results demonstrate the following:

  • RhPV1 virus stocks are infectious in vivo; animal seroconvert
  • 3/5 animals show evidence of low grade squamous intraepithelial lesions (LGSIL)
  • Persistent RhPV1 genomes are found in Pap smears from the animals

Advantages/Applications

A non-human primate animal model infection system for the study of HPV-induced anogenital infections, preneoplasia, and cancers is of tremendous benefit to research. It has numerous advantages compared to rodent models:

  • Natural Sexual Transmission Route / Experimental Oral Route
  • Interaction with other Relevant Pathogens/Cofactors
  • AIDS from Simian Immunodeficiency Virus (SIV; related to HIV)
  • Oral contraceptives/hormones
  • Tobacco products
  • Inflammation
  • Effects of Genital Hormones / Menstrual Cycle
  • Relevant Anatomy & Physiology (very different from rodents)
  • Primate uterine anatomy -- squamo-columnar junction
  • Hormone responsiveness
  • Physiology of infection site
  • Mucosal immune system
  • Progression to Neoplasia
  • Test efficacy of prophylactic and therapeutic agents
  • Study the molecular bases for the effectiveness of prophylactic and therapeutic agents

INQUIRES

STC has filed intellectual property on this exciting new technology and is currently exploring commercialization options. If you are interested in information about this or other technologies, please contact Arlene Mirabal at amirabal@stc.unm.edu or 505-272-7886.

Files

File Name Description
7,285,386 Issued Patent None Download

Intellectual Property

Patent Number Issue Date Type Country of Filing
7,285,386 None Utility United States