There has been significant interest recently on the development of chip-based nanofluidic systems for molecular separations, especially of biomolecules, based on nanoscale phenomena including entropic trapping and shear-driven chromatography. In addition to a limited number of experimental efforts, there have been several important theoretical studies that have sought to elucidate the effects of nanoconfinement of liquids on the molecular distributions and trajectories in electrokinetic flows. Thus far, theoretical investigation of the effects of nanoconfinement on electrokinetic transport of fluids has outpaced experiments because the details of such fluid flows have been unobservable by routine far-field or near-field techniques.
This technology includes methodologies for investigation of electrokinetic transport in channels with characteristic length scales of nanoscopic dimensions; shows how data obtained can be compared with analytical models for fluid transport within very small channels; and explores the potential for the use of nanoconfined electrokinetic transport in the development of new methodologies for molecular separation.
- Feasible for high throughput applications
- Cheaper, faster, and easier than existing methods
- Eliminates the need for skilled technicians
- Nanochannel devices specified to desired results
An application of Nanoelectrokinetic Separation is for the separation of biomolecular and nonbiomolecular particles. Additional applications include molecular and biomolecular identification or biosensing and in chromatographic separations.
Electrostatic Potential and Electroosmotic Flow in a Cylindrical Capillary Filled with Symmetric Electrolyte: Analytic Solutions in Thin Double Layer Approximation. Petsev, D., Lopez, G.P., J. Coll. Interface Sci., 2006, vol. 294, pp. 492-498.
An Electrokinetic Cell Model for Analysis and Optimization of Electroosmotic Pumps. Piyasena, M.E., Lopez, G.P, Petsev, D.N., Sens. & Actuat. B, 2006, vol. 113, pp. 461-467.
Electrokinetic molecular separation in nanoscale fluidic channels. Garcia, A. L., Ista, L. K., Petsev, D. N., O'Brien, M. J.; Bisong, P., Mammoli, A. A., Brueck, S. R. J., Lopez, G. P., The Royal Society of Chemistry, 2005, vol. 5, pp. 1271-1276.
STC has filed intellectual property on this exciting new technology and is currently exploring commercialization options. If you are interested in information about this or other technologies, please contact Arlene Mirabal at email@example.com or 505-272-7886.