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Project TitleDetection and Delivery Systems Utilizing Supported Lipid Bilayers
Track Code2006-017
Short Description

This is a platform technology which provides new and sensitive supported lipid bilayer membrane systems

Abstract

The membrane systems provided by the invention include lipid membranes supported on porous microspheres or microbeads. These beads are stable and can be used with immunoassays and for analysis of membrane structures while in suspension, or in columns, or in microfluidic systems. A large variety of agents can be incorporated into the lipid bilayer coated beads. For example, materials encapsulated within the supported lipid bilayers can include, for example, a therapeutic agent, a detectable label, a pharmaceutical, an antiseptic reagent, a chemical compound, a peptide, a protein, an antibody, an oligonucleotide, a nucleic acid, a lipid, a carbohydrate, a fertilizer, an herbicide, an insecticide, or any other molecule. The agents incorporated into the lipid bilayer coated beads/particles can be targeted for release into specific tissues or sites in the body by incorporating targeting agents. The targeting agent can be a receptor that recognizes a ligand that may be associated with a disease or condition. Additionally, the supported lipid bilayer can encapsulate the materials for targeted, slow, sustained, or timed release.

 
Tagsdrug delivery, microfluidics
 
Posted DateJan 29, 2015

Researcher

Name
Gabriel Lopez
Sireesha Chemburu
S. D. Menake Piyasena
Reema Zeineldin

Manager

Name
Jovan Heusser

Background

An understanding of interactions between membrane active biomolecules, test agents, and surfactants on model lip bilayer membranes is needed for many purposes, including, for example, drug design and developing an understanding of complex interactions in native biological membranes. Most disruption studies utilizing model membrane systems have used lipid vesicles or supported lipid membranes (SLM) on flat surfaces. The instability and poorly defined structures of lipid vesicles limit their utility and essentially preclude their use in miniaturized technologies such as microfluidics. Part of the problem with lipid vesicles and supported lipid membranes on flat surfaces is due to the difficulties faced when trying to integrate these membranes into analytical and other devices. Thus, new model membrane systems and methods for analyzing membrane structure are needed. Such membranes and methods can be used in clinical, environmental, and bioanalytical applications.

Technology Description

This is a platform technology which provides new and sensitive supported lipid bilayer membrane systems and methods of using the supported lipid bilayer systems in analytical assays and delivery systems. The membrane systems provided by the invention include lipid membranes supported on porous microspheres or microbeads. These beads are stable and can be used with immunoassays and for analysis of membrane structures while in suspension, or in columns, or in microfluidic systems.

 

A large variety of agents can be incorporated into the lipid bilayer coated beads. For example, materials encapsulated within the supported lipid bilayers can include, for example, a therapeutic agent, a detectable label, a pharmaceutical, an antiseptic reagent, a chemical compound, a peptide, a protein, an antibody, an oligonucleotide, a nucleic acid, a lipid, a carbohydrate, a fertilizer, an herbicide, an insecticide, or any other molecule. The agents incorporated into the lipid bilayer coated beads/particles can be targeted for release into specific tissues or sites in the body by incorporating “targeting agents.” The targeting agent can be a receptor that recognizes a ligand that may be associated with a disease or condition. Additionally, the supported lipid bilayer can encapsulate the materials for targeted, slow, sustained, or timed release.

Advantages/Applications

The supported lipid bilayer membrane systems provided by this invention represent a new form of vehicle for a broad range of applications, including, pharmaceutical, agricultural, analytical and related applications.

Commercial applications include:

  • Encapsulation and delivery of therapeutic agents useful for treatment of inflammation, viral infection, bacterial infection, autoimmune diseases, heart disease, cancer and other diseases and conditions. 
  • Encapsulation of detectable labels to form reagents useful for detection of diseases and conditions such as inflammation, viral infection, bacterial infection, autoimmune diseases, heart disease, cancer and the like.
  • Encapsulation of detectable label that is useful for detection and analysis of factors in the environment.

Additionally, this technology enables:

  • Detection methods that include fluorescence, modulation, and flow cytometry
  • Detection methods of antigens binding to an antibody. The antigen can be a viral antigen (including HIV), a cancer antigen, a bacterial antigen, a fungal antigen, an autoimmune antigen or a combination thereof.
  • A kit comprising a suspension of beads or microbead of the invention, and solution of molecules that can modulate a signal from the dye contained within the microbeads.

Publications

INQUIRES

STC has filed intellectual property on this exciting new technology and is currently exploring commercialization options. If you are interested in information about this or other technologies, please contact Arlene Mirabal at amirabal@stc.unm.edu or 505-272-7886.

Files

File Name Description
8,465,983 Issued Patent None Download
8,334,107 Issued Patent None Download
7,514,267 Issued Patent None Download

Intellectual Property

Patent Number Issue Date Type Country of Filing
8,465,983 None Utility United States
7,514,267 None Utility United States
8,334,107 None Divisional United States