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Project TitleA Sensitive and Simple Method for Detection of Occult Blood in Biological Samples
Track Code2002-036
Short Description

This invention provides a simple fluorometric method which avoids the disadvantages of guaiac-based and immunologic tests.

Abstract

At least 1,000 times more sensitive than the currently available commercial kits, this fluorimetric method has been used to detect a single erythrocyte in a tissue section. In addition, this test can give quantitative assessments of blood loss.

 
Tagsdiagnostics, occult blood, diagnostic kits
 
Posted DateApr 11, 2014

Researcher

Name
Shimin Liu
Ke Jian Liu

Manager

Name
Jovan Heusser

Background

The ability to detect occult blood assists in the early diagnosis of a variety of conditions, for example, colorectal cancer. Several different kinds of tests for occult blood are commercially available. Several of these tests are based on the immunologic recognition of intact human hemoglobulin. Such tests are limited by insensitivity to hemoglobin that is denatured, either in sample processing or by passing through the upper GI tract. Several other tests make use of the pseudoperoxidase activity of hemoglobin or free heme detected by guaiac, an oxidation-sensitive dye. Such tests suffer from a high rate of false positives. When these tests are used, patients are instructed to avoid eating red meat or turnips and to avoid the use of aspirin and other non-steroidal anti-inflammatory drugs or vitamin C for at least two days. 

 

Despite the limitations of currently available fecal occult blood tests, annual screening is recommended by the United States Preventive Services Task Force, the World Health Organization, and the American Cancer Society.

Technology Description

This invention provides a simple fluorometric method which avoids the disadvantages of guaiac-based and immunologic tests. At least 1,000 times more sensitive than the currently available commercial kits, this fluorimetric method has been used to detect a single erythrocyte in a tissue section. In addition, this test can give quantitative assessments of blood loss.

Advantages/Applications

This simple and economical test: 

  • Will reduce the likelihood of false positive and false negative results 
  • Is at least 1,000 times more sensitive than the currently available commercial kits
  • Can detect a single erythrocyte in a tissue section 
  • Can give quantitative assessments of blood loss

Publications

INQUIRES

STC has filed intellectual property on this exciting new technology and is currently exploring commercialization options. If you are interested in information about this or other technologies, please contact Arlene Mirabal at amirabal@stc.unm.edu or 505-272-7886.

Files

File Name Description
7,223,604 Issued Patent None Download

Intellectual Property

Patent Number Issue Date Type Country of Filing
7,223,604 May 29, 2007 Utility United States