Phospholipid bilayer membranes (PBMs), transmembrane proteins and their
assemblies are essential components of all cellular systems that enable a
variety of functions including compartmentalization, passive and active
transport, signal transduction, specific recognition and energy
utilization. Because of their versatility in function, scientists have
long sought to incorporate PBMs into artificial materials and devices
that have a broad range of potential applications.
Biological components and biological architectures are attractive
for use in electronic/photonic/chemical devices because they represent
the ultimate in “smart” nanomaterials, exhibiting complex functions and
responses to stimuli not possible with purely artificial materials.
Unfortunately, the full potential for incorporation of such components
and architectures into practical devices has not been realized due to a
number of obstacles. Chief among the obstacles for development of
biomembrance mimics has been their fragility of membranes in almost
every environment except carefully controlled laboratory settings.
Moreover, there is a lack of well-defined active model systems for
transmembrane protein complexes and related biomolecular membrane
systems, which are among nature’s most versatile molecular machines.
A need exists for robust membrane models that include lipids,
biologically active proteins and complexes capable of mimicking natural
biological processes. Moreover, simple methods are needed for making
these robust membrane systems. This technology includes simple methods
for creating these robust membrane models.
The methods of the present invention permit manufacture of rugged hybrid
bio-synthetic materials and devices that can exhibit selective and
active transport function in a wide range of processes, devices and
The hybrid lipid lamellar assemblies can be used for controlled drug
delivery, biosensing for drug discovery, medical diagnosis,
environmental monitoring, chemical and biological agent sequestration,
actuator development and bio-fuel cell development. The methods and
devices of this invention can be used for a variety of applications,
including detection of chemical and biological warfare agents, chemical
and biological warfare defense through agent sequestration or repulsion,
mobile power generation, and multifunctional fabrics for combat
situations, including those capable of reduction of heat stress.
Robust Hybrid Thin Films that Incorporate Lamellar Phospholipid Bilayer Assemblies and Transmembrane Proteins. Gupta, G., Atanassov, P., and Lopez, G.P., Biointerphases, 2006, vol. 1, issue 1, pp. 6-10.
STC has filed intellectual property on this exciting new technology and is currently exploring commercialization options. If you are interested in information about this or other technologies, please contact Arlene Mirabal at email@example.com or 505-272-7886.