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Project TitleRobust Hybrid Thin Films that Incorporate Lamellar Phospholipid Bilayer Assemblies and Transmembrane Proteins
Track Code2006-066
Short Description

The methods of the present invention permit manufacture of rugged hybrid bio-synthetic materials and devices that can exhibit selective and active transport function in a wide range of processes, devices and environmental conditions.

Abstract

The methods of the present invention permit manufacture of rugged hybrid bio-synthetic materials and devices that can exhibit selective and active transport function in a wide range of processes, devices and environmental conditions.

 
Tagsbiosensing, biodefense, membranes, drug delivery
 
Posted DateAug 8, 2011

Researcher

Name
Plamen Atanassov
Gabriel Lopez
Gautam Gupta

Manager

Name
Briana Wobbe

Background

Phospholipid bilayer membranes (PBMs), transmembrane proteins and their assemblies are essential components of all cellular systems that enable a variety of functions including compartmentalization, passive and active transport, signal transduction, specific recognition and energy utilization. Because of their versatility in function, scientists have long sought to incorporate PBMs into artificial materials and devices that have a broad range of potential applications.

Biological components and biological architectures are attractive for use in electronic/photonic/chemical devices because they represent the ultimate in “smart” nanomaterials, exhibiting complex functions and responses to stimuli not possible with purely artificial materials. Unfortunately, the full potential for incorporation of such components and architectures into practical devices has not been realized due to a number of obstacles. Chief among the obstacles for development of biomembrance mimics has been their fragility of membranes in almost every environment except carefully controlled laboratory settings. Moreover, there is a lack of well-defined active model systems for transmembrane protein complexes and related biomolecular membrane systems, which are among nature’s most versatile molecular machines. 

A need exists for robust membrane models that include lipids, biologically active proteins and complexes capable of mimicking natural biological processes. Moreover, simple methods are needed for making these robust membrane systems. This technology includes simple methods for creating these robust membrane models.

Technology Description

The methods of the present invention permit manufacture of rugged hybrid bio-synthetic materials and devices that can exhibit selective and active transport function in a wide range of processes, devices and environmental conditions.

Advantages/Applications

The hybrid lipid lamellar assemblies can be used for controlled drug delivery, biosensing for drug discovery, medical diagnosis, environmental monitoring, chemical and biological agent sequestration, actuator development and bio-fuel cell development. The methods and devices of this invention can be used for a variety of applications, including detection of chemical and biological warfare agents, chemical and biological warfare defense through agent sequestration or repulsion, mobile power generation, and multifunctional fabrics for combat situations, including those capable of reduction of heat stress.

Publications

Robust Hybrid Thin Films that Incorporate Lamellar Phospholipid Bilayer Assemblies and Transmembrane Proteins. Gupta, G., Atanassov, P., and Lopez, G.P., Biointerphases, 2006, vol. 1, issue 1, pp. 6-10.

INQUIRES

STC has filed intellectual property on this exciting new technology and is currently exploring commercialization options. If you are interested in information about this or other technologies, please contact Arlene Mirabal at amirabal@stc.unm.edu or 505-272-7886.

Files

File Name Description
US 2012/0058327 Published Patent Application None Download
8,114,464 Issued Patent None Download

Intellectual Property

Patent Number Issue Date Type Country of Filing
8,114,464 None Utility United States