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Project TitleBio-Compatible Hybrid Organic/Inorganic Gels: Vapor Phase Synthesis
Track Code2007-065
Short Description

This technology builds on 2006-066 and provides a novel approach and device to immobilize cells, liposomes, enzymes and proteins and planar lipid bilayers in gels.

Abstract

This technology builds on 2006-066 and provides a novel approach and device to immobilize cells, liposomes, enzymes and proteins and planar lipid bilayers in gels. This approach utilizes a gelling process based on vapor phase synthesis. Specimens are exposed for a specific amount of time to differing vapors which form a porous gel that allows substrates and products to enter and leave the system while immobilizing and retaining the subject material (cells, enzymes, liposomes, proteins, or planar lipid bilayers).

 
Tagsdrug delivery, biosensor, Biofuel Cells
 
Posted DateJan 11, 2011 4:00 PM

Researcher

Name
Plamen Atanassov
Gabriel Lopez
Gautam Gupta

Manager

Name
Briana Wobbe

Background

Robust synthetic hybrid bio-materials have become one of the most innovative research areas due to rising demand and multiple uses. These materials are growing in popularity because they exhibit mechanical stability, long shelf life, low-toxicity, bio compatibility and efficient transport of molecules in and out of these systems. Applications such as, biosensors (optical, electrochemical), drug delivery, bio-fuel cells (enzymatic, whole cell), micro reactors (cells) active transport systems and photonic devices, are just a few that are enhanced with these materials.

Another STC.UNM technology, 2006-066, provides for manufacture of rugged hybrid bio-synthetic materials and devices that can exhibit selective and active transport function in a wide range of processes, devices and environmental conditions.

Technology Description

This technology builds on 2006-066 and provides a novel approach and device to immobilize cells, liposomes, enzymes and proteins and planar lipid bilayers in gels. This approach utilizes a gelling process based on vapor phase synthesis. Specimens are exposed for a specific amount of time to differing vapors which form a porous gel that allows substrates and products to enter and leave the system while immobilizing and retaining the subject material (cells, enzymes, liposomes, proteins, or planar lipid bilayers).

Advantages/Applications

This process is universally compatible with biological and non biological species. Furthermore, it is simple, efficient, versatile, and has low energy requirements. The main advantages are:

  • Exceptional flexibility and versatility
    • Thin films or bulk gels
    • Long shelf life
    • Can be applied to a conductive substrate or form free standing membranes
    • Membranes can be spin coated on silicon wafers
    • Complete pH range (1-12) and varied ionic strength
    • Bulk gels can be used as microreactors
  • Simple and energy efficient
    • Short-exposure time 
    • Room temperature synthesis (37°C, 60°C). Higher temperature shortens gel time.
  • Low toxicity

This technology enables unlimited, diverse applications, which can revolutionize new, upcoming technologies. Applications include:

  • Drug Delivery
  • Biosensors (optical/electrochemical)
  • Biofuel cells (enzymatic/whole cell)
  • Micro reactors (cells)
  • Active or passive transport systems
  • Photonic devices

Publications

CVD for the Facile Synthesis of Hybrid Nanobiomaterials Integrating Functional Supramolecular Assemblies
Gautam Gupta, Shailendra B. Rathod, Kyle W. Staggs, Linnea K. Ista, Kaoutar Abbou Oucherif, Plamen B. Atanassov, Michaelann S. Tartis, Gabriel A. Montao and Gabriel P. Lopez; Langmuir, 2009, 25 (23), pp 13322–13327

INQUIRES

STC has filed intellectual property on this exciting new technology and is currently exploring commercialization options. If you are interested in information about this or other technologies, please contact Arlene Mirabal at amirabal@stc.unm.edu or 505-272-7886.

Files

File Name Description
8,252,607 Issued Patent None Download

Intellectual Property

Patent Number Issue Date Type Country of Filing
8,252,607 None Utility United States