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Project TitleSynergistic Neuroprotective Drugs Isolated from Chinese Herbs
Track Code2016-088
Short Description

Synergistic neuroprotective treatments against brain injury caused by cerebral ischemia or low oxygen environments.

Abstract

Drugs may be developed that have significant neuroprotective potential for reducing ischemia/reperfusion injury in hospital emergency setting, or for reducing the discomfort associated with visiting high altitude region as a dietary supplement.

 
Tagsneuroprotectant, stroke, ischemia, hypoxia
 
Posted DateAug 1, 2017 11:06 AM

Researcher

Name
Ke Jian Liu
Jiangang Shen

Manager

Name
Jovan Heusser

Background

Injury caused to the brain by hypoxia and reperfusion are often times the most serious consequences of major medical emergencies including stroke, cardiac arrest, hypoxia and other brain trauma. Currently, it is estimated that a human brain can survive less than 5 minutes in ischemic conditions before irreparable neurological damage is sustained. In such patients, even if oxygen can be restored to the brain, there is still great potential for injury due to rapid reoxygenation of neural tissue that is likely to occur following a period of hypoxia to the brain. As such, a class of drugs that presents neuroprotective potential for reduction of ischemia/reperfusion injury is of great interest in to the medical community, which is capable of increasing the window of opportunity to save the lives of critically injured patients as well as improving their likely neurological outcome. Such a class of drugs would not only of great importance in the field of emergency medicine, but may also have lifesaving potential to high risk patients suffering from chronic conditions placing them at risk for ischemia/reperfusion injury such as those with hypertension, atherosclerosis or individuals with concern of being exposed to low oxygen environments, like visiting high altitude regions.

Technology Description

Researchers from the University of New Mexico and the University of Hong Kong have discovered synergistic neuroprotective treatments against brain injury caused by cerebral ischemia or low oxygen environments. Drugs may be developed that have significant neuroprotective potential for reducing ischemia/reperfusion injury in hospital emergency setting, or for reducing the discomfort associated with visiting high altitude region as a dietary supplement.

Advantages/Applications

  •  Provides synergistic neuroprotection
  • Drug strategy would be much superior to a single drug therapeutic approach for improving therapeutic outcome in ischemic stroke treatment and hypoxia conditions
  • Protects blood-brain barrier (BBB) integrity and reduce infarction volume in experimental ischemic stroke model
  • Applicable to cerebral ischemia-reperfusion injury such as stoke
  • Can be used as a dietary supplement for reducing mountain sickness syndromes

INQUIRES

STC has filed intellectual property on this exciting new technology and is currently exploring commercialization options. If you are interested in information about this or other technologies, please contact Arlene Mirabal at amirabal@stc.unm.edu or 505-272-7886.