Go to Top
INVENTOR LOGIN

Details

Project TitleProximity-Assisted Protein Labeling in Living Cells
Track Code2013-080
Short Description

A novel technology that can be used to monitor or manipulate any chosen cellular protein with a large variety of synthetic chemical probes for various biological and biomedical applications. 

Abstract

The developed protein-labeling system is proximity-assisted, enabling the insertion of chemical probes with high efficiency and specificity.  This technology addresses multiple limitations associated with current methods and provides a superior and more broadly applicable protein-labeling platform. 

 
Tagsbiomedical research, protein labeling
 
Posted DateSep 21, 2016 3:55 PM

Researcher

Name
Fu-Sen Liang

Manager

Name
Jovan Heusser

Background

Discovering the complex mechanisms behind a wide range of biological processes and human diseases starts with understanding the functions of cellular proteins.  Enhancing our knowledge of these proteins can also contribute significantly to the development of novel therapies and diagnostics, two major goals of biomedical research.  A related branch of technology that allows investigators to modify or label chosen proteins with specific functionalities or probes in living cells is key in achieving these goals.  Various methods already exist and are used to modify and label proteins of choice, and these provide unparalleled labeling specificity and are easily applied to and used in the studies of various biological processes.  While these techniques have proven to be effective, they have their share of problems and limitations.  One major barrier that keeps these methods from obtaining a more general use is their limited targeting specificity and coupling efficiency in attaching these probes to chosen proteins within the cell.  A technology void of this problem would be ideal and would make the use of probes to monitor and manipulate specific proteins within a cell more efficient as well as more widely applicable.

Technology Description

A researcher at the University of New Mexico has developed a novel technology that can be used to monitor or manipulate any chosen cellular protein with a large variety of synthetic chemical probes for various biological and biomedical applications.  The developed protein-labeling system is proximity-assisted, enabling the insertion of chemical probes with high efficiency and specificity. This technology addresses multiple limitations associated with current methods and provides a superior and more broadly applicable protein-labeling platform. 

Advantages/Applications

  • Potentially transformational application to life science research
  • A superior and more broadly applicable protein-labeling platform
  • Applications in various fields of biological and biomedical research
  • A proximity-assisted protein-labeling system that allows for the insertion of probes with high efficiency and specificity

INQUIRES

STC has filed intellectual property on this exciting new technology and is currently exploring commercialization options. If you are interested in information about this or other technologies, please contact Arlene Mirabal at amirabal@stc.unm.edu or 505-272-7886.