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Project TitleNanopatterned Surface Motility Based Separations, Removal and Destruction of Bacteria
Track Code2014-114
Short Description

A method to separate, remove, and/or destroy bacteria based on their surface motility.

Abstract

Twitching profiles for several different strains and/or species of bacteria on self-assembled monolayers (SAMs) of w-substituted alkanethiolates on gold have been recently obtained. In addition, a unique nanopatterning technique and system can be incorporated to optimize the removal and destruction of separated cells.  After the cells are separated, cells may be removed from the surfaces for subsequent analysis.  

 
Tagsdecontamination, bacteria, bioseparation
 
Posted DateAug 1, 2017 11:04 AM

Researcher

Name
Gabriel Lopez
Linnea Ista

Manager

Name
Jovan Heusser

Background

Surface motility (e.g. twitiching, swarming, gliding) may be used to differentiate different types of bacteria, based on velocity and/or directionality of the cells on different substrata. Researchers have recently shown differential surface motility of some bacteria on self-assembled monolayers (SAMs) of w-substituted alkanethiolates on gold with different chemistries. It has been proposed as an effective separation method wherein chemical and spatial gradients of substratum chemistries promote the accumulation of different strains of bacteria at different locations on the substratum gradient, thus providing preliminary separation and identification of species of interest; furthermore the substratum chemistry can be modified to release bacteria for different evaluations or to kill bacteria in situ.  

Technology Description

Researchers at the University of New Mexico have developed a method to separate, remove, and/or destroy bacteria based on their surface motility.  Twitching profiles for several different strains and/or species of bacteria on self-assembled monolayers (SAMs) of w-substituted alkanethiolates on gold have been recently obtained. In addition, a unique nanopatterning technique and system can be incorporated to optimize the removal and destruction of separated cells. After the cells are separated, cells may be removed from the surfaces for subsequent analysis. 

Advantages/Applications

  • Bacteria can be separated based on their affinity for different substratum chemistries and/or the spatial organization of the relevant motility apparatus
  • Unlike targets of other identification methods (e.g. immunological methods), the molecular genetics of motility systems are both poorly understood and complex, resulting in lower probability of tampering with the organisms to avoid detection
  • Further analysis or destruction of separated cells can be accomplished
  • Applications include, but are not limited to: bioseparations, biowarfare agent detection and destruction, sensing, and decontamination of small devices
  • Method provides an effective tool for the investigation of surface motility

INQUIRES

STC has filed intellectual property on this exciting new technology and is currently exploring commercialization options. If you are interested in information about this or other technologies, please contact Arlene Mirabal at amirabal@stc.unm.edu or 505-272-7886.