Cells constantly sense their microenvironments and integrate
perceived signals to generate proper cellular responses. Synthetic biology aims
to engineer novel cellular functions by assembling molecular parts to enable
the detection and processing of specific signals to give predictable and
desired biological outputs. These efforts not only contribute to the
understanding of how sophisticated cellular behaviors are built, but also hold
great promise of providing novel therapeutic applications.
Gene and cell therapies have shown great promise for treating
various human diseases including neurodegenerative diseases, cancers and
metabolic disorders, among others. However, the administration of desired
therapeutic effects at precise pathologic tissue region is still difficult to achieve
due to the complexity of the in vivo
Researchers at the University of New Mexico have developed a
novel interdisciplinary approach, which enables a chosen endogenous cellular
signal or biomarker to induce tailored cellular responses. It is anticipated
that this new strategy will be a useful tool for synthetic biologists and
ultimately, will be applicable to the development of gene and cell therapies.
STC has filed intellectual property on this exciting new technology and is currently exploring commercialization options. If you are interested in information about this or other technologies, please contact Arlene Mirabal at firstname.lastname@example.org or 505-272-7886.