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Project TitleCell Signal-Induced Protein Proximity for Cellular Processes Regulation and Human Disease Therapy
Track Code2014-072
Short Description

A novel interdisciplinary approach, which enables a chosen endogenous cellular signal or biomarker to induce tailored cellular responses.

Abstract

It is anticipated that this new strategy will be a useful tool for synthetic biologists and ultimately, will be applicable to the development of gene and cell therapies.

 
Tagscell therapy, gene therapy
 
Posted DateJun 3, 2014 3:28 PM

Researcher

Name
Wei Wang
Fu-Sen Liang

Manager

Name
Jovan Heusser

Background

Cells constantly sense their microenvironments and integrate perceived signals to generate proper cellular responses. Synthetic biology aims to engineer novel cellular functions by assembling molecular parts to enable the detection and processing of specific signals to give predictable and desired biological outputs. These efforts not only contribute to the understanding of how sophisticated cellular behaviors are built, but also hold great promise of providing novel therapeutic applications.

Gene and cell therapies have shown great promise for treating various human diseases including neurodegenerative diseases, cancers and metabolic disorders, among others. However, the administration of desired therapeutic effects at precise pathologic tissue region is still difficult to achieve due to the complexity of the in vivo environment.

Technology Description

Researchers at the University of New Mexico have developed a novel interdisciplinary approach, which enables a chosen endogenous cellular signal or biomarker to induce tailored cellular responses. It is anticipated that this new strategy will be a useful tool for synthetic biologists and ultimately, will be applicable to the development of gene and cell therapies.

Advantages/Applications

  • Enable cells to detect disease signals and make decisions following pre-defined rules
  • Allows for predictable and desired biological outputs
  • Able to control gene expression or other desired cellular events
  • Provides a better understanding of how sophisticated cellular behaviors are built
  • Applicable to the development of gene and cell therapies

Publications

INQUIRES

STC has filed intellectual property on this exciting new technology and is currently exploring commercialization options. If you are interested in information about this or other technologies, please contact Arlene Mirabal at amirabal@stc.unm.edu or 505-272-7886.

Files

File Name Description
US 2017/0226595 A1 Published Patent Application None Download